.
| Road | From | To | Notes |
|---|
| A6 | Luton | Carlisle | |
| A60 | Loughborough | Doncaster | |
| A61 | Derby | Thirsk | |
| A62 | Manchester | Leeds | Former main Trans Pennine route from Lancashire to Yorkshire |
| A63 | Leeds | Kingston-upon-Hull | |
| A64 | Leeds | Scarborough | Main road from West Yorkshire to the East Coast. |
| A65 | Leeds | Kendal | Trans Pennine route. |
| A66 | Near Redcar | Workington | |
| A67 | Bowes | Crathorne | |
| A68 | Darlington | Edinburgh | |
| A69 | Denton Burn | Carlisle | |
| A600 | Hitchin | Bedford | |
| A601 | | | Derby Inner Ring Road |
| A602 | Hitchin | Ware | |
| A603 | Fenlake | Sandy | |
| A604 | Kettering | Harwich | Now superseded by the A14 |
| A605 | A14 Junction 13 | Hobbs Lot Bridge | |
| A606 | Stamford | West Bridgford | |
| A607 | Leicester | Lincoln | |
| A608 | Mansfield | Derby | |
| A609 | Nottingham | Ilkeston | |
| A610 | Nottingham | Matlock | |
| A611 | Nottingham | Mansfield | |
| A612 | Nottingham | Newark-on-Trent | |
| A614 | Calverton | Bridlington | |
| A615 | Near Clay Cross | Matlock | |
| A616 | Newark-on-Trent | Huddersfield | |
| A617 | Chesterfield | Newark-on-Trent | |
| A618 | Clowne | Rotherham | |
| A619 | Bakewell | Worksop | |
| A620 | Ranby | Beckingham | |
| A621 | Sheffield | Baslow | |
| A623 | Chapel-en-le-Frith | Baslow | |
| A624 | Glossop | Chapel-en-le-Frith | Prior to rerouting of the A6 via Chapel-en-le-Frith this used to go as far as Buxton |
| A625 | Sheffield | A623 | Re routed following collapse of part of the route |
| A626 | Glossop | Heaton Chapel | |
| A627 | Hazel Grove | Rochdale | Between Oldham and Rochdale runs as the A627(M) |
| A628 | Hollingworth | Pontefract | Trans Pennine route. |
| A629 | Rotherham | Skipton | |
| A630 | Sheffield | M18 Junction 4 | |
| A631 | Greenland | Pontefract | |
| A632 | Matlock | Cuckney | |
| A633 | Rotherham | Smithies | |
| A634 | Maltby | A638 near Retford | |
| A635 | Manchester | Doncaster | Trans Pennine route. |
| A636 | Denby Dale | Wakefield | |
| A637 | Gawber | Grange Moor | |
| A638 | A1 at Markham Moor | M62 Chain Bar junction | |
| A639 | Skellow | Leeds | |
| A640 | Rochdale | Huddersfield | Trans Pennine route. |
| A641 | Huddersfield | Bradford | Main road between Huddersfield and Bradford. |
| A642 | Wakefield | Garforth | |
| A643 | M62 Junction 23 | Leeds | |
| A644 | Dewsbury | Denholme Clough | |
| A645 | Wakefield | Snaith | |
| A646 | Halifax | Burnley | |
| A647 | Leeds | Halifax | |
| A649 | Liversedge | Hipperholme | |
| A650 | Wakefield | Keighley | |
| A651 | Liversedge | East Bierley | |
| A652 | Dewsbury | Gomersal | |
| A653 | Dewsbury | Leeds | |
| A654 | Tingley | Oulton | |
| A655 | near Wakefield | Castleford | |
| A656 | Castleford | Aberford | |
| A657 | Shipley | Leeds | |
| A658 | Bradford | A59 east of Knaresborough | |
| A659 | Tadcaster | Otley | |
| A660 | Leeds | Burley in Wharfedale | |
| A661 | Wetherby | Harrogate | |
| A662 | Manchester | Droylsden | |
| A663 | Failsworth | Newhey | |
| A664 | Manchester | Rochdale | |
| A665 | Manchester | Ainsworth Junction with A58 | |
| A666 | Pendlebury | Langho | |
| A667 | Kearsley | Whitefield | |
| A669 | Middleton | Grasscroft | |
| A670 | Ashton Under Lyne | Diggle | |
| A671 | Oldham | Worston | |
| A672 | Oldham | Ripponden | |
| A673 | Bolton | Heath Charnock | |
| A674 | Chorley | Blackburn | |
| A675 | Bolton | Preston | |
| A676 | Hunger Hill | Bolton | |
| A677 | Blackburn | Samlesbury | |
| A678 | Blackburn | Padiham | |
| A679 | Blackburn | Burnley | |
| A680 | Rochdale | Whalley | |
| A681 | Haslingden | Todmorden | |
| A682 | Holme | Long Preston | Part of the road is the most dangerous in the UK |
| A683 | Heysham | Kirkby Stephen | |
| A684 | Kendal | A19 east of Ellerbeck | |
| A685 | Kendal | Brough | |
| A686 | Penrith | Haydon Bridge | |
| A687 | Ingleton | Cantsfield | |
| A688 | Barnard Castle | Bowburn | |
| A689 | M6 Junction 44 | Hartlepool | |
| A690 | Crook | Sunderland | |
| A691 | Consett | Durham | |
| A692 | Castleside | A1 near Gateshead | |
| A693 | Leadgate | Chester-le-Street | |
| A694 | Consett | A1 near MetroCentre | |
| A695 | Newcastle-upon-Tyne | Hexham | |
| A696 | Otterburn | Newcastle-upon-Tyne | |
| A697 | Fair Moor | Oxton | |
| A698 | Berwick | Hawick | |
| A699 | Selkirk | Kelso | |
| A6003 | Great Oakley | Oakham | |
| A6004 | Loughborough | Loughborough railway station | |
| A6006 | Hathern | Melton Mowbray | |
| A6007 | Codnor | Trowell | |
| A6010 | Chorlton-cum-Hardy | Cheetham | An Eastern Loop around Manchester |
| A6013 | Ladybower Reservoir | Bamford | This number also occurs in Kettering, Northamptonshire |
| A6014 | Corby | Corby | |
| A6015 | Hayfield | Newtown, New Mills | |
| A6016 | Glossop | Glossop | Linking the A57 with the A624 |
| A6017 | Bredbury | Ashton-Under-Lyne | |
| A6018 | Mottram in Longdendale | Stalybridge | |
| A6019 | Nottingham | Nottingham | A Short stretch of road in Nottingham city centre |
| A6020 | Ashford-in-the-Water | A619 near Bakewell | Acts as a by-pass for Bakewell |
| A6021 | South East Rotherham | South West Rotherham | |
| A6022 | Mexborough | Swinton | |
| A6023 | Wath upon Dearne | Conisborough | |
| A6024 | A628 at Woodhead | Honley | |
| A6025 | Brighouse | A629 near Elland | |
| A6026 | A58 near Sowerby Bridge | A629 near Greetland | |
| A6027 | Horwich | Horwich | |
| A6030 | A563 near Hamilton | A6 near Oadby | |
| A6032 | Castleford | Castleford | |
| A6033 | Littleborough | Haworth | |
| A6035 | Keighley | Keighley | |
| A6036 | Halifax | Bradford | |
| A6037 | Shipley | Bradford | |
| A6038 | Shipley | Otley | |
| A6040 | Harrogate | Harrogate | |
| A6041 | Manchester | Salford | |
| A6042 | Manchester | Manchester | Forms the western section of the Manchester & Salford Inner Relief Route |
| A6044 | Pendlebury | Heaton Park | |
| A6045 | Heywood | Heaton Park | |
| A6046 | Heywood | Middleton | |
| A6048 | Oldham | Oldham | |
| A6050 | A670 near Mossley | A669 near Lydgate | |
| A6051 | Greenfield | Greenfield | |
| A6052 | Uppermill | Denshaw | |
| A6053 | Kearsley | A56 near Bury | |
| A6055 | Knaresborough | Boroughbridge | |
| A6068 | Kildwick | Near Accrington | |
| A6071 | Brampton | Gretna | |
| A6075 | Sutton in Ashfield | Darlton | |
| A6094 | Leadburn | Wallyford | |
| A6097 | Bingham | Warren Hill | |
| A6101 | Rivelin, Sheffield | Hillsborough, Sheffield | |
| A6102 | Bowshaw | Deepcar | |
| A6104 | Hathershaw | Prestwich | |
| A6105 | Earlston | Berwick-upon-Tweed | |
| A6107 | A643 near Brighouse | A62 at Bradley | |
| A6108 | Scotch Corner | Ripon | |
| A6109 | Sheffield | Rotherham | |
| A6110 | Beeston, Leeds | Bramley, Leeds | Part of the Leeds Outer Ring Road. |
| A6116 | Thrapston | Rockingham | |
| A6120 | A647 | M1 Junction 46 | Part of the Leeds Outer Ring Road. |
| A6123 | South East Rotherham | North Rotherham | |
| A6129 | Welwyn | Welwyn | |
| A6134 | | | Part of the Sheffield Inner Ring Road |
| A6135 | Lenton | Mapperley Park | |
| A6136 | Richmond | A1 | |
| A6140 | Ashton-under-Lyne | Guide Bridge | Most of its route is the Ashton-Under-Lyne Northern By-Pass |
| A6141 | Letchworth | Baldock | |
| A6144 | Lymm | Stretford | Includes the Carrington Spur, formerly the A6144(M) |
| A6175 | Clay Cross | M1 | |
| A6176 | Ravenscliffe | Bolton | |
| A6177 | Bradford | Bradford | |
| A6178 | Rotherham | Sheffield | |
| A6079 | Hexham | A68 road | |
| A6182 | M18 motorway Junction 3 | Doncaster | |
| A6185 | Rishton | A679 | |
| A6187 | A625 | Castleton | Part of the former route of the A625 |
| A6195 | M1 Junction 36 | Shafton | |
| A6200 | Nottingham | Nottingham | |
| A6211 | Woodthorpe, Arnold | Gedling, Carlton | |
| A6514 | Arnold | Wollaton | Nottingham Ring Road, later named A52 |