ALPHA OPERON RIBOSOME BINDING SITE

The 'alpha operon ribosome binding site' in bacteria is surrounded by this complex pseudoknotted RNA structure. Translation of the mRNA produces 4 ribosomal protein products, one of which (S4) acts as a translational repressor by binding to the nested pseudoknot region. The mechanism of repression is thought to involve a conformational switch in the pseudoknot region and ribosome entrapment.^[1]

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Reference

1. Translational repression of the ''Escherichia coli'' alpha operon mRNA: importance of an mRNA conformational switch and a ternary entrapment complex, , PJ, Schlax, J Biol Chem, 2001

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