ASPARTATE TRANSAMINASE

'Aspartate transaminase' ('AST') also called 'serum glutamic oxaloacetic transaminase' ('SGOT') or 'aspartate aminotransferase' ('ASAT/AAT') () is similar to alanine transaminase (ALT) in that it is another enzyme associated with liver parenchymal cells.

Contents

Function

Isozymes

Clinical significance

External links

External links

Function

It facilitates the conversion of aspartate and alpha-ketoglutaric acid to oxaloacetate and glutamate.

Isozymes

Two isoenzymes are present in humans. They have high similarity.

★ , the cytosolic isoenzyme derives mainly from red blood cells and heart.

★ , the mitochondrial isoenzyme is predominantly present in liver.

Clinical significance

It is raised in acute liver damage. It is also present in red blood cells and cardiac muscle.
SGOT/AST is commonly measured clinically as a part of a diagnostic liver function test, to determine liver health.

External links

★ Aspartate aminotransferase of Escherichia coli: nucleotide sequence of the aspC gene, Kuramitsu S, Okuno S, Ogawa T, Ogawa H, Kagamiyama H, , , J. Biochem., 1985

★ The complete amino acid sequence of aspartate aminotransferase from Escherichia coli: sequence comparison with pig isoenzymes, Kondo K, Wakabayashi S, Yagi T, Kagamiyama H, , , Biochem. Biophys. Res. Commun., 1984

★ Site-directed mutagenesis of Escherichia coli aspartate aminotransferase: role of Tyr70 in the catalytic processes, Inoue K, Kuramitsu S, Okamoto A, Hirotsu K, Higuchi T, Kagamiyama H, , , Biochemistry, 1991

External links

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