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'Avram Hershko' (, born 'Herskó Ferenc', 31 December 1937) is an Israeli biologist.
Born in Karcag, Jász-Nagykun-Szolnok county, Hungary, he received his M.D. in 1965 and his Ph. D in 1969 from the Hadassah Faculty of Medicine in the Hebrew University of Jerusalem. He is currently a Distinguished Professor at the Rappaport Family Institute for Research in Medical Sciences at the Technion in Haifa and Adjunct Professor of Pathology at New York University.
In 2000 he received the Albert Lasker Award for Basic Medical Research. Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
★ 1987 - Weizmann Prize for Sciences (Israel)
★ 1993 - Elected to the European Molecular Biology Organization
★ 1994 - Israel Prize in Biochemistry and Medicine
★ 1999 - Wachter Prize, by the University of Innsbruck, Austria (with A. Ciechanover)
★ 1999 - Gairdner International Award, by the Gairdner Foundation, Canada (with A. Varshavsky)
★ 2000 - Albert Lasker Award for Basic Medical Research
★ 2004 - Nobel Prize in Chemistry
★ Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". ''Proc. Natl. Acad. Sci. USA'' 76, pp. 3107-3110.
★ Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". ''Proc. Natl. Acad. Sci. USA'' 77, pp. 1783-1786.
★ Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982) Covalent affinity purification of ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
★ Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
★ Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619-1623.
★ Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
★ Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
★ Nobel citation
★ Website at the Technion
★ "Hungarian" Nobel Prize winners Crooked Timber
★ Avram Hershko Jewish Virtual Library
★ Ubiquitin-Mediated Protein Degradation: From the lab to the bedside Dan Hersko
★ Avram Hershko & Aaron Ciechanover, 2004 Nobel in Chemistry - A web article
Born in Karcag, Jász-Nagykun-Szolnok county, Hungary, he received his M.D. in 1965 and his Ph. D in 1969 from the Hadassah Faculty of Medicine in the Hebrew University of Jerusalem. He is currently a Distinguished Professor at the Rappaport Family Institute for Research in Medical Sciences at the Technion in Haifa and Adjunct Professor of Pathology at New York University.
In 2000 he received the Albert Lasker Award for Basic Medical Research. Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
| Contents |
| Honors and awards |
| Publications |
| External links |
Honors and awards
★ 1987 - Weizmann Prize for Sciences (Israel)
★ 1993 - Elected to the European Molecular Biology Organization
★ 1994 - Israel Prize in Biochemistry and Medicine
★ 1999 - Wachter Prize, by the University of Innsbruck, Austria (with A. Ciechanover)
★ 1999 - Gairdner International Award, by the Gairdner Foundation, Canada (with A. Varshavsky)
★ 2000 - Albert Lasker Award for Basic Medical Research
★ 2004 - Nobel Prize in Chemistry
Publications
★ Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". ''Proc. Natl. Acad. Sci. USA'' 76, pp. 3107-3110.
★ Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". ''Proc. Natl. Acad. Sci. USA'' 77, pp. 1783-1786.
★ Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982) Covalent affinity purification of ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
★ Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
★ Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619-1623.
★ Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
★ Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
External links
★ Nobel citation
★ Website at the Technion
★ "Hungarian" Nobel Prize winners Crooked Timber
★ Avram Hershko Jewish Virtual Library
★ Ubiquitin-Mediated Protein Degradation: From the lab to the bedside Dan Hersko
★ Avram Hershko & Aaron Ciechanover, 2004 Nobel in Chemistry - A web article
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