AZOLE
An 'azole' is a class of five-membered nitrogen heterocyclic ring compounds containing at least one other noncarbon atom, nitrogen, sulfur or oxygen. The parent compounds are aromatic and have two double bonds; there are successively reduced analogs (azolines and azolidines) with less. Names of azoles maintain the prefix upon reduction (such as pyrazoline, pyrazolidine), except for pyrrole, which has no -azole suffix and is reduced to pyrroline and pyrrolidine.
The azoles include:
★ 1 nitrogen
★
★ pyrrole
★ 2 or more nitrogen atoms
★
★ pyrazole
★
★ imidazole, included in histidine
★
★ triazole, included in Ribavirin
★
★ tetrazole
★ 1 nitrogen atom and 1 oxygen atom
★
★ oxazole
★
★ isoxazole
★ 1 nitrogen atom and 1 sulfur atom
★
★ thiazole
★
★ isothiazole
A "dioxole" is a similar compound with two oxygen atoms in a five membered ring. Dioxolane is a derivative of dioxole.
Many azoles are used as antifungal drugs, inhibiting the fungal enzyme 14α-demethylase which produces ergosterol.
This article provided by Wikipedia. To edit the contents of this article, click here for original source.
psst.. try this: add to faves

العربية
中国
Français
Deutsch
Ελληνική
हिन्दी
Italiano
日本語
Português
Русский
Español

