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'Barbara Manfredi' (1444 - 1466) was the wife of Pino III Ordelaffi, lord of Forlì (Italy).
She was born in Faenza, current Emilia-Romagna, to Astorre II Manfredi, seignior of that city. At the age seven she was bethrothed to the powerful Pino III Ordelaffi, who married her in 1462.
The following year Pino became ill. His brother Francesco (Cecco) was suspected of poisoning him, but the Forlivese lord survived. However, when in 1466 Francesco fell ill in turn, and Barbara attempted to poison him. Cecco was in the end assassinated by one of his officers, and Pino could be the sole lord of the city, maintaining that position thanks the support of Venice.
However, when Barbara suddenly died, the jealous Pino was accused by Astorre of poisoning her. The magnificent sepulchre that her husband commissioned her (now in the Abbey of San Mercuriale in Forlì) was seen as a proof of his guilty conscience.