CDGSH IRON SULFUR DOMAIN

The 'CDGSH iron sulfur domain' are a group of iron-sulfur (Fe-S) clusters and a unique 39 amino acid CDGSH domain ['C'-X-C-X2-(S/T)-X3-P-X-C-'D'-'G'-('S'/A/T)-'H'].
The CDGSH iron sulfur domain 1 protein (also referred to as 'mitoNEET') is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.^[1] Iron in turn is essential for the function of several mitochondrial enzymes.
The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.^[2]

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References

1. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone, Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA, , , Proc. Natl. Acad. Sci. U.S.A., 2007
2. Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe, Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, Lund ET, Mathews WR, , , Am. J. Physiol. Endocrinol. Metab., 2004

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