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'Charles V' may refer to:

★ Charles V the Wise (1338–1380), King of France.

★ Charles V (1500–1558), Holy Roman Emperor (as Charles V) and King of Spain (as Charles I)

★ Charles V (1643–1690), Duke of Lorraine

★ Charles V (1661–1700), King of Spain (as Charles II) and of Naples (as Charles V)

★ Infante Carlos of Spain, Count of Molina (1788-1855), first Carlist pretender to the throne of Spain (as Charles V)