CILASTATIN

{{drugbox
| IUPAC_name = (''Z'')-7-[(2''S'')-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1''S'')-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
| image = Cilastatin.svg
| CAS_number = 82009-34-5
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| PubChem = 5280454
| DrugBank = EXPT00918
| C=16|H=26|N=2|O=5|S=1
| molecular_weight = 358.454 g/mol
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'Cilastatin' is a chemical compound which inhibits the human enzyme dehydropeptidase. ^[1]
Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin in and of itself does not have any antibacterial activity.

Contents

References

See also

References

1. The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA, Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ, , , Antimicrob. Agents Chemother., 1995

See also

★ Imipenem/cilastatin