CIS-REGULATORY ELEMENT

A 'cis-regulatory element' or cis-element is a region of DNA or RNA which regulates the expression of genes located on that same strand. This term is constructed from the Latin root -cis, which means "on the same side as". These cis-regulatory elements are often binding sites of one or more trans-acting factors. A cis-element may be located in the promoter region 5' to the gene it controls, in the intron, or in the 3' region.
In contrast, trans-regulatory elements are species which may modify the expression of genes distant from the gene that was originally transcribed to create them. To demonstrate the concept (this is not a specific example), a transcription factor which regulates a gene on chromosome 6 might itself have been transcribed from a gene on chromosome 11. This term is constructed from the Latin root -trans, which means "across from".
To summarize, -cis elements are present on the same strand as the gene they regulate whereas -trans elements can regulate genes distant from the gene they were transcribed from.

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External references

See also

See also

External references

★ Wray, G. A. 2007. The evolutionary significance of cis-regulatory mutations. Nature Reviews Genetics 8, 206-216

★ Gompel et al. 2005. Chance caught on the wing: ''cis'' regulation evolution and the origin of pigmentation patterns in ''Drosophila''. Nature 433: 481-487.

★ Prud'homme et al. 2006. Repeated morphological evolution through ''cis'' regulatory changes in a pleiotropic gene. Nature 440: 1050-1053.

★ Stern, D.L. 2000. Perspective: Evolutionary developmental biology and the problem of variation. Evolution 54: 1079-1091.

★ Carroll, S.B., Grenier, J.K. and Weatherbee, S.D. 2005. "From DNA to diversity: Molecular genetics and the evolution of animal design" Blackwell publishing

See also

DNA

★ TATA box

★ Pribnow box

★ SOS box

★ CAAT box

★ CCAAT box

★ Operator (biology)
RNA

★ SECIS element, mRNA

★ Polyadenylation signals, mRNA

★ Iron Responsive Element, mRNA

See also

★ Regulation of gene expression

★ Cis-acting element

★ Gene regulatory network

★ Operon

★ Promoter

★ Trans-acting factor