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'Coagulase' is an enzyme produced by ''Staphylococcus aureus'' that converts fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of ''Staphylococcus'' isolates. Coagulase negativity excludes ''S. aureus''.
Coagulase reacts with prothrombin in the blood. The resulting complex is called ''staphylothrombin'', which causes blood to clot by converting fibrinogen to fibrin. Coagulase is tightly bound to the surface of the bacteria ''S. aureus'' and can coat its surface with fibrin upon contact with blood. It has been proposed that fibrin-coated staphylococci resist phagocytosis making the bacteria more virulent. Bound coagulase is part of the larger family of MSCRAMMS
'The coagulase test' is used to differentiate ''Staphylococcus aureus'' from the other species of ''Staphylococcus''. The test uses rabbit plasma that has been inoculated with a staphylococcal colony. The tube is then incubated at 37 degrees Celsius for 1-1/2 hours. If positive (i.e. the suspect colony is ''S. aureus''), the serum will coagulate, resulting in a clot (sometimes the clot is so pronounced that the liquid will completely solidify). If negative (i.e. the suspect colony is ''S. epidermidis''), the plasma remains liquid.
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Coagulase reacts with prothrombin in the blood. The resulting complex is called ''staphylothrombin'', which causes blood to clot by converting fibrinogen to fibrin. Coagulase is tightly bound to the surface of the bacteria ''S. aureus'' and can coat its surface with fibrin upon contact with blood. It has been proposed that fibrin-coated staphylococci resist phagocytosis making the bacteria more virulent. Bound coagulase is part of the larger family of MSCRAMMS
'The coagulase test' is used to differentiate ''Staphylococcus aureus'' from the other species of ''Staphylococcus''. The test uses rabbit plasma that has been inoculated with a staphylococcal colony. The tube is then incubated at 37 degrees Celsius for 1-1/2 hours. If positive (i.e. the suspect colony is ''S. aureus''), the serum will coagulate, resulting in a clot (sometimes the clot is so pronounced that the liquid will completely solidify). If negative (i.e. the suspect colony is ''S. epidermidis''), the plasma remains liquid.
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