'Darien' may refer to:
In or associated with the Panama/Colombia area:

★ Darién Province, Panama

★ Santa María la Antigua del Darién, the town founded by Vasco Núñez de Balboa in Panama in 1510

★ Darien scheme, a disastrous campaign by the Company of Scotland to found a Scottish colony in Panama in the 17th c.

★ Darién National Park, Panama

★ Darién Gap, an area straddling the border of Panama and Colombia

★ Gulf of Darién, a gulf of the Caribbean Sea extending into Colombia near the border with Panama

★ Darién, a brand of bananas distributed in the United States by Colombian company Turbana
In the United States of America:

★ Darien, Connecticut

★ Darien, Georgia

★ Darien, Illinois, a suburb of Chicago

★ Darien, New York

★ Darien (town), Wisconsin

★ Darien, Wisconsin, a village the town of Darien
Other:

★ Darien, the former transliteration of the name of Dalian in China

★ Darien, the anglicized name of Chiba Mamoru (Tuxedo Mask) in the Sailor Moon anime

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