DIHYDROXYACETONE PHOSPHATE

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Dihydroxyacetone phosphate
Chemical name
Other names	Dihydroxyacetone phosphate DHAP
Chemical formula
Molecular mass	g/mol
CAS number	[]
Melting point	°C
SMILES

'Dihydroxyacetone phosphate' (DHAP) is a biochemical compound involved in many reactions, from the Calvin cycle in plants to the ether-lipid biosynthesis process in ''Leishmania mexicana''. Its major biochemical role is in the glycolysis metabolic pathway. DHAP may be referred to as glycerone phosphate in older texts.

Contents

Dihydroxyacetone phosphate in glycolysis

Dihydroxyacetone phosphate in other pathways

See also

External links

Dihydroxyacetone phosphate in glycolysis

Dihydroxyacetone phosphate lies in the glycolysis metabolic pathway, and is one of the two products of breakdown of fructose 1,6-phosphate, along with glyceraldehyde 3-phosphate. It is rapidly, reversibly, isomerised to glyceraldehyde 3-phosphate.
''The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.''

Dihydroxyacetone phosphate in other pathways

In the Calvin cycle, DHAP is one of the products of the sixfold reduction of 1,3-bisphosphoglycerate by NADPH. It is also used in the synthesis of sedoheptulose 1,7-bisphosphate and fructose 1,6-bisphosphate which are both used to reform ribulose 5-phosphate, the 'key' carbohydrate of the Calvin cycle.
DHAP is also the product of the dehydrogenation of L-glycerol-3-phosphate which is part of the entry of glycerol (sourced from triglycerides) into the glycolytic pathway. Conversely, reduction of glycolysis-derived DHAP to L-glyercol-3-phosphate provides adipose cells with the activated glycerol backbone they require to synthesize new triglycerides. Both reactions are catalyzed by the enzyme 'glycerol 3-phosphate dehydrogenase' with NAD⁺/NADH as cofactor.

See also

★ Dihydroxyacetone

External links