DYSBINDIN

'Dysbindin', short for 'dystrobrevin-binding protein 1', is a protein constituent of the dystrophin-associated protein complex of skeletal muscle cells. Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin.^[1] In addition, dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus.

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Implications for Schizophrenia

References

External links

Implications for Schizophrenia

Much interest in dysbindin has arisen through pedigree-based family-association studies of families with a history of schizophrenia, where a strong association was found between expression of a particular dysbindin allele and a clinical expression of schizophrenia.^[2] However, the exact link between dysbindin and schizophrenia remains highly controversial.

References

1. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain, Benson et al, , , J Biol Chem, 2001
2. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia, Straub et al, , , Am J Hum Genet, 2002

External links

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