ENFLURANE

'Enflurane' (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966.
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.

Contents

Physical properties

Side Effects

External links

Physical properties

Property	Value
Boiling point at 1 atm	56.5 °C
MAC	1.68
Vapor pressure at 20 °C	22.9 kPa (172 mm Hg)
Blood: Gas Partition Coefficient	1.9
Oil: Gas Partition Coefficient	98

Side Effects

Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.
Enflurane also lowers the threshold for seizures and should especially not be used on people with epilepsy. It is also thought to cause malignant hyperthermia in rare cases.

External links