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'Fluke' may refer to:

★ another term for flounder, flatfish that live in ocean waters. Many of the other meanings of the term derive from this flat shape.

★ a common name for trematoda, a class of flatworms; for example, the liver fluke

★ Fluke (band), an electronic dance music group

★ Fluke Corporation, a manufacturer of electrical and electronic test equipment such as multimeters and oscilloscopes

★ ''Fluke'' (film), a 1995 film

★ ''Fluke, or, I Know Why the Winged Whale Sings'', a 2003 novel by Christopher Moore