GRID.ORG

'grid.org' was the website and organization that ran distributed computing projects such as the United Devices Cancer Research Project. It retired on April 27, 2007.^[1] It was sponsored by United Devices (UD) and members contributed by running the UD Agent software (version 3.0).

Contents

Projects

Cancer Research Project

Human Proteome Folding Project, phase 1

Smallpox Project

Anthrax Project

HMMER Project

Webload Project

See also

References

External links

Projects

Cancer Research Project

The United Devices Cancer Research Project, which began in 2001, was seeking possible drugs for the treatment of cancer using distributed computer power.^[2] There were around 150,000 users in the United States and 170,000 in Europe along with hundreds of thousands more in other parts of the world.
The project is an alliance of several companies and organisations:^[3]

★ United Devices Inc.

★ National Foundation for Cancer Research

★ University of Oxford Department of Chemistry

★ Donors of molecular research
United Devices released the cancer research screensaver under the principle of utilising spare computing power. The program, which can also be set to run continually, uses "virtual screening" to find possible interactions between molecules and target proteins, i.e. a drug. These molecules (ligands) are sent to the host computer's UD Agent. When these molecules dock successfully with a target protein this interaction is scored for further investigation.
The research consisted of two phases:

★ Phase 1 tested over 3 billion drug-like molecules against 12 proteins which were known to be suitable targets for anti-cancer drugs. It used the "THINK" software for the simulation of the molecular interactions.^[4]

★ Phase 2, using the "LigandFit" software developed by Accelrys to model interactions, sought to refine the Phase 1 data to produce a more manageable list of drug candidates for testing that would require experimental collaborators, including some from industry.^[5][6]

Human Proteome Folding Project, phase 1

Main articles: Human Proteome Folding Project

The IBM-sponsored ''Human Proteome Folding Project'' ("HPF"), phase 1, was announced on November 16, 2004 and was completed July 3, 2006. The project operated simultaneously on both grid.org and the IBM's World Community Grid.^[7]
It made use of the "Rosetta" software to predict the structure of human proteins in order to help predict the function of proteins. This information may someday be used to help cure a variety of diseases and genetic defects.
According to an announcement on the grid.org forums,^[8] after the HPF1 project was completed it was left to continue running on grid.org until August 9, 2006.^[9] During that time, members whose computers were configured to run this project got new work and spent computing resources calculating a result, but the result was returned to grid.org for points only -- it was not used for scientific research.
The status of the Human Proteome Folding Project caused some discussion on the grid.org forums. Most members wanted to see all available computing power directed toward the still-active Cancer project, but UD representative Robby Brewer asserted that "some [users] like the screensaver".^[10] As noted above, in the end the redundant HPF1 work on grid.org was halted.

Smallpox Project

The ''Smallpox Research Grid'' was a part of United Devices "Patriot Grid" initiative to fight biological terrorism. This project helped analyze potential drug candidates for a medical therapy in the fight against smallpox virus. It made use of the "LigandFit" software (that had already been used by phase 2 of the Cancer Research project), but with a specialized set of target molecules that targeted the smallpox virus.^[11] 35 million potential drug molecules were screened against several smallpox proteins, resulting in 44 strong potential treatments.
The partners of the project included University of Oxford, the University of Western Ontario, Memorial Sloan Kettering Cancer Research Center, Essex University, Evotec OAI, Accelrys, and IBM.^[12]
The World Community Grid largely began because of the success of this project in shaving years off research time.

Anthrax Project

The ''Anthrax Research Project'' was a part of the United Devices "Patriot Grid" initiative to fight biological terrorism. It made use of the "LigandFit" software (that had already been used by phase 2 of the Cancer Research project), but with a specialized set of target molecules that targeted the advanced stages of anthrax bacterial infection.
The project was operated from January 22, 2002 until February 14, 2002 and ended after a total of 3.57 billion molecules had finished screening. The results of the research project were transmitted to biological scientists in order to finish the screening of the computational simulations.^[13]
The partners of the project included Oxford University.

HMMER Project

The ''HMMER Genetic Research'' project made use of the Hidden Markov model to search for patterns in genetic DNA sequences.^[14]

Webload Project

The ''Web Performance Testing'' project was operated as a commercial opportunity with select web hosting providers in order to help them test the scalability of their server infrastructures under periods of high-demand.^[15]

See also

★ List of distributed computing projects

References

1. All Good Things Come To An End…
2. Screensaver aids cancer fight
3. Cancer Project Participants
4. Think phase 1 computation
5. LigandFit explained
6. Phase 2 of the Project
7. About The Human Proteome Folding Project
8. Grid.org Status
9. Take responsibility
10. Grid.org status
11. About The Smallpox Project
12. Smallpox participants
13. The Anthrax Research Project
14. Genetic Testing with HMMR
15. Web Performance Testing

External links

★ Grid.org

★ The National Foundation for Cancer Research

★ United Devices Inc.

★ Department of Chemistry at the University of Oxford

★ Evotec OAI - drug R&D company