HLA-DR17

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR17
Haplotypes groups	DRA ★ 01:DRB1 ★ 0301 DRA ★ 01:DRB1 ★ 0304
'Structure' (See HLA-DR)
'Identifiers'	alpha '' ★ 0101''
Symbol(s)	HLA-DRA
EBI-HLA	★ class=wikiexternal target=_blank>0101 DRA ★ 0101
'Identifiers'	beta 1 '' ★ 0301'' '' ★ 0304''
Symbol(s)	HLA-DRB1
EBI-HLA	★ class=wikiexternal target=_blank>0301 DRB1 ★ 0301
EBI-HLA	★ class=wikiexternal target=_blank>0304 DRB1 ★ 0304
'Shared data'
Locus	chr.6 ''6p21.31''

'HLA-DR17' (DR17) is an HLA-DR serotype that recognizes the DRB1
★ 0301 and
★ 0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.
=Serology=

DR17 and DR3 recognition of some DRB1
★ 03 alleles^[1]

DRB1 ★	'DR17'	DR3	DR18	Sample
allele	%	%	%	size (N)
0301	64	33	0	9698
0304	20	60		5

DR17 recognizes the DRB1
★ 0301,
★ 0304 alleles.
=Disease associations=

Contents

By serotype

By allele

By haplotype

By phenotype

By serotype

DR17 is associated with non-chronic sarcoidosis^[2][3], infantile spasm/epilepsy^[4], rabies vaccine-induced autoimmune encephalomyelitis^[5] and cardiovascular hypertrophy in subjects with arterial hypertension^[6] People with DR17 show a tendancy toward benzylpenicilloyl allergies.^[7]

By allele

'DRB1
★ 0301': diabetes mellitus type 1 HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients., Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M, , , Bratisl Lek Listy, 2006 , myositis^[8], early onset Graves disease^[9], type 1 autoimmune hepatitis^[10], inflammatory inclusion body myositis An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families., Sivakumar K, Semino-Mora C, Dalakas M, , , Brain, . In autoimmune hepatitis,
DRB1
★ 0301 correlates with more severe and difficult to treat disease.^[11]

By haplotype

'DRB1
★ 0301:DQA1
★ 05:DQB1
★ 0201' is associated with diabetes mellitus type 1^[12], ovarian cancer^[13], non-thymomic myasthenia gravis ^[14], idiopathic inflammatory myopathies ^[15], non-cancer associated Lambert-Eaton myasthenic syndrome^[16]

By phenotype

The 'DRB1
★ 0301/DRB1
★ 1501' heterozygote is linked to primary Sjögren's syndrome^[17]
=Genetic Linkage=

DR17 Haplotypes
Serotypes	DRA	DRB1	DRB3
DR17	★ 0101	★ 0301	0101
	★ 0101	★ 0301	0201
Serotypes	DQA1	DQB1	DRB1
DR17(3)-DQ2(2.5)	★ 0501	★ 0201	★ 0301
Serotypes	HLA-A	HLA C	HLA B	DRB1
A1-Cw7-B8-DR17(3)	★ 0101	★ 0701	★ 0801	★ 0301
A2-Cw7-B8-DR17(3)	★ 0201	★ 0701	★ 0801	★ 0301
A30-Cw5-B18-DR17(3)	★ 3002	★ 0501	★ 1801	★ 0301

HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes
are the result of gene products from the HLA-DRB3
★ and HLA DQA1
★ 0501 and HLA DQB1
★ 0201 alleles.
DRB1
★ 0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:
A
★ 0101 : Cw
★ 0701 : B
★ 0801 : DRB1
★ 0301 : DQA1
★ 0501 : DQB1
★ 0201
This haplotype is known as "Super B8" or "European ancestral haplotype"
=References=
1. derived from IMGT/HLA
2. HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis., Berlin M, Fogdell-Hahn A, Olerup O, Eklund A, Grunewald J, , , Am J Respir Crit Care Med, 1997
3. T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis., Planck A, Katchar K, Eklund A, Gripenbäck S, Grunewald J, , , Sarcoidosis Vasc Diffuse Lung Dis, 2003
4. Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos., Suastegui R, De La Rosa G, Carranza J, Gonzalez-Astiazaran A, Gorodezky C, , , Epilepsia, 2001
5. Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis., Piyasirisilp S, Schmeckpeper B, Chandanayingyong D, Hemachudha T, Griffin D, , , Ann Neurol, 1999
6. Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives., Diamantopoulos E, Andreadis E, Vassilopoulos C, Vlachonikolis I, Tarassi K, Chatzis N, Giannakopoulos N, Papasteriades C, , , Am J Hypertens, 2001
7. HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins, Yang J, Qiao HL, Zhang YW, Jia LJ, Tian X, Gao N, , , Chin. Med. J., 2006
8. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies., O'Hanlon T, Carrick D, Targoff I, Arnett F, Reveille J, Carrington M, Gao X, Oddis C, Morel P, Malley J, Malley K, Shamim E, Rider L, Chanock S, Foster C, Bunch T, Blackshear P, Plotz P, Love L, Miller F, , , Medicine (Baltimore), 2006
9. HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB1
★ 0701,DQA1
★ 0201 haplotype., Lavard L, Madsen H, Perrild H, Jacobsen B, Svejgaard A, , , Tissue Antigens, 1997
10. Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis., Czaja A, Strettell M, Thomson L, Santrach P, Moore S, Donaldson P, Williams R, , , Hepatology, 1997
11. Current therapy for autoimmune hepatitis, Montano Loza AJ, Czaja AJ, , , Nature clinical practice. Gastroenterology & hepatology, 2007
12. Is the Association Between TNF-alpha-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?, Deja G, Jarosz-Chobot P, Polańska J, Siekiera U, Małecka-Tendera E, , , Mediators Inflamm, 2006
13. HLA-class II haplotype associations with ovarian cancer., Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K, , , Int J Cancer, 2006
14. Correlation of thymic pathology with HLA in myasthenia gravis., Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, Izbicki J, , , Clin Immunol, 1999
15. Update on the genetics of the idiopathic inflammatory myopathies., Shamim E, Rider L, Miller F, , , Curr Opin Rheumatol, 2000
16. Increased frequency of HLA class II alleles DRB1
★ 0301 and DQB1
★ 0201 in Lambert-Eaton myasthenic syndrome without associated cancer., Parsons K, Kwok W, Gaur L, Nepom G, , , Hum Immunol, 2000
17. DRB1
★ 15 and DRB1
★ 03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility., Jean S, Quelvennec E, Alizadeh M, Guggenbuhl P, Birebent B, Perdriger A, Grosbois B, Pawlotsky P, Semana G, , , Clin Exp Rheumatol,