HLA-DR3

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR3
Haplotypes groups	DRA ★ 01:DRB1 ★ 0301 DRA ★ 01:DRB1 ★ 0302 DRA ★ 01:DRB1 ★ 0303 DRA ★ 01:DRB1 ★ 0304
'Structure' (See HLA-DR)
'Identifiers'	alpha '' ★ 0101''
Symbol(s)	HLA-DRA
EBI-HLA	★ class=wikiexternal target=_blank>0101 DRA ★ 0101
'Identifiers'	beta 1 '' ★ 0301'' '' ★ 0301'' '' ★ 0302'' '' ★ 0303'' '' ★ 0304''
Symbol(s)	HLA-DRB1
EBI-HLA	★ class=wikiexternal target=_blank>0301 DRB1 ★ 0301
EBI-HLA	★ class=wikiexternal target=_blank>0302 DRB1 ★ 0302
EBI-HLA	★ class=wikiexternal target=_blank>0303 DRB1 ★ 0303
EBI-HLA	★ class=wikiexternal target=_blank>0304 DRB1 ★ 0304
EBI-HLA	★ class=wikiexternal target=_blank>0305 DRB1 ★ 0305
'Shared data'
Locus	chr.6 ''6p21.31''

'HLA-DR3' is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes.
=Serology=

DR17 and DR3 recognition of some DRB1
★ 03 alleles^[1]

DRB1 ★	'DR3'	DR17	DR18	Sample
allele	%	%	%	size (N)
0301	33	64	0	9698
0302	24	3	66	317
0303	40		60	5
0304	60	20		5
0307	>50			1

Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1
★ 0304 primarily reacts with DR3. The serotypes of
★ 0305,
★ 0306,
★ 0308 to
★ 0331 are unknown.

=Disease associations=

Contents

By serotype

By allele

By haplotypes

By serotype

'HLA-DR3' is associated with early-age onset myasthenia gravis, primary sclerosing cholangitis,^[2] and opportunistic infections in AIDS^[3], but lowered risk for cancers^[4].

By allele

DRB1
★ 0301 (see HLA-DR17)
DRB1
★ 0302 (See HLA-DR18)
DRB1
★ 0304 is associated it graves disease , , , , ,

By haplotypes

DR3 and/or DQ2 is associated with Moreen's ulceration^[5], "bout onset" multiple schlerosis^[6], Grave's disease^[7] and systemic lupus erythematosus^[8]
DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, juvenile diabetes. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1
★ 0501 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however is older studies DQA1
★ 0505 is commonly confused with DQA1
★ 0501)

=Genetic linkage=
DR3 is genetically linked to HLA-DR52, DRB3
★ 0202 allele, and HLA-DQ2 (DQ2.5).
=References=
1. derived from IMGT/HLA
2. Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes, Wiencke K, Karlsen TH, Boberg KM, ''et al'', , , Tissue Antigens, 2007
3. HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections, Pollack MS, Gold J, Metroka CE, Safai B, Dupont B, , , Hum. Immunol., 1984
4. HLA antigen frequencies in HIV-1-related Kaposi's sarcoma, Mann DL, Murray C, O'Donnell M, Blattner WA, Goedert JJ, , , J. Acquir. Immune Defic. Syndr., 1990
5. HLA and Mooren's ulceration., Taylor C, Smith S, Morgan C, Stephenson S, Key T, Srinivasan M, Cunningham E, Watson P, , , Br J Ophthalmol, 2000
6. Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study., Weinshenker B, Santrach P, Bissonet A, McDonnell S, Schaid D, Moore S, Rodriguez M, , , Neurology, 1998
7. MHC-extended haplotypes in families of patients with Graves' disease., Ratanachaiyavong S, Lloyd L, Darke C, McGregor A, , , Hum Immunol, 1993
8. Synergetic effect between interleukin-1 receptor antagonist allele (IL1RN
★ 2) and MHC class II (DR17,DQ2) in determining susceptibility to systemic lupus erythematosus., Tjernström F, Hellmer G, Nived O, Truedsson L, Sturfelt G, , , Lupus, 1999