HITACHIMYCIN

'Hitachimycin', also known as 'stubomycin', is a cyclic polypeptide produced by ''Streptomyces'' that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.^[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic.^[2]
As of 2007, it has not been used in a clinical setting.

Contents

References

References

1. Studies on the biological activity of stubomycin, Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I, , , J. Antibiot., 1983
2. A new antitumor antibiotic, stubomycin, Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M, , , J. Antibiot., 1981