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'Edward of Portugal' (Portuguese language: ''Duarte'', pron. IPA []) - (Lisbon, October 7 1515-Lisbon, September 20 1540).
4th Duke of Guimarães and Prince of Portugal, was the sixth son of King Manuel I of Portugal and his wife Maria of Aragon.
In 1537 he married Isabel of Braganza, daughter of James, 4th Duke of Braganza, who was dowried as the ''Duchess of Guimaraes'' in her own right.
This marriage produced three children:

★ Maria of Guimarães (1538-1577), married Alessandro Farnese, Duke of Parma and Piacenza.

★ Catherine of Guimarães (1540-1614), Duchess of Braganza, married to John, 6th Duke of Braganza, she was a claimant of the throne of Portugal in 1580 (''See: Struggle for the throne of Portugal).

★ Edward, Duke of Guimaraes (1541-1576)
He is buried in the Monastery of Jerónimos in Lisbon.