INTERLEUKIN 10

'Interleukin-10' (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.

Contents

Function

Expression

Gene and Protein Structure

External links

Function

It is capable of inhibiting synthesis of pro-inflammatory cytokines like Interferon-gamma, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and the Type 1 T helper cells.
IL-10 also displays potent abilities to suppress the antigen presentation capactiy of antigen presenting cells.
However, it is also stimulatory towards certain T cells, mast cells and B cells.

Expression

It is mainly expressed in monocytes and Type 2 T helper cells (T_H2), mast cells and also in a certain subset of activated T cells and B cells.
It is released by cytotoxic T-cells to inhibit the actions of NK cells during the immune response to viral infection.

Gene and Protein Structure

In humans, the IL-10 gene is located in chromosome 1 and consists of 5 exons.
The IL-10 protein is a homodimer . Each subunit is 178 amino acids long.

External links

★