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EspañolINTRAUTERINE DEVICE
An 'intra-uterine device' (''intra'' meaning ''within'', and ''uterine'' meaning ''of the uterus'') is a birth control device also known as an 'IUD' or a 'coil' (this colloquialism is based on the coil-shaped design of early IUDs). It is a device placed in the uterus and is the world's most widely used method of reversible birth control,[1] currently used by nearly 160 million women (just over two-thirds of whom are in China where it is the most widely used birth control method, surpassing sterilization).[2] The device has to be fitted inside or removed from the uterus by a doctor or qualified medical practitioner. It remains in place the entire time pregnancy is not desired. Depending on the type, a single IUD is approved for 5 to 10 years use (the copper T 380A is effective for at least 12 years).[3]
Types of IUDs
There are two broad categories of intrauterine contraceptive devices: inert and copper-based devices, and hormonally-based devices that work by releasing a progestogen.
In the United States, there are two types of intrauterine contraceptive available; the copper Paragard and the hormonal Mirena. In the U.S. both of these contraceptives are referred to as IUDs.[4]
In the United Kingdom, the term IUD only refers to inert or copper-containing devices, (seven types of copper-containing IUDs are available in the UK). In the UK, hormonal uterine contraceptives are considered as a separate form of contraception from IUDs, and they are distinguished with the term IntraUterine System or IUS.28[5]
Most non-hormonal IUDs have a plastic T-shaped frame that is wrapped with copper and/or has copper bands. In some IUDs, such as the Nova T 380, the pure copper wire has a silver core which has been shown to prevent breaking of the wire.28[6]
The arms of the frame hold the IUD in place near the top of the uterus. The GyneFix does not have a T-shape, but rather is a loop that holds several copper tubes. The GyneFix is held in place by a suture to the fundus of the uterus. All copper-containing IUDs have a number as part of their name. This is the surface area of copper (in square millimeters) the IUD provides.
Effectiveness and mechanism of contraception
All second-generation copper-T IUDs have failure rates of less than 1% per year, and cumulative 10-year failure rates of 2-6%.[7]
A large WHO trial reported a cumulative 12-year failure rate of 2.2% for the T 380A (ParaGard) (an average failure rate of 0.18% per year over 12 years), equivalent to a cumulative 10-year failure rate of 1.8% following tubal ligation. The frameless GyneFix also has a failure rate of less than 1% per year.[8] Worldwide, older IUD models with lower effectiveness rates are no longer produced.[9]
The presence of a device in the uterus prompts the release of leukocytes and prostaglandins by the endometrium. These substances are hostile to both sperm and eggs; the presence of copper increases this spermicidal effect.[10][11] While the primary mechanism of action of the IUD is spermicidal/ovicidal, post-fertilization mechanisms are believed by some Christian pro-life physicians to contribute significantly to their effectiveness.[12] Because many pro-life individuals and organizations define fertilization as the beginning of pregnancy, this possible secondary mechanism of action has led some pro-life individuals and organizations to label the IUD an abortifacient.
Some barrier contraceptives protect against STDs. Hormonal contraceptives reduce the risk of developing pelvic inflammatory disease (PID), a serious complication of certain STDs. IUDs, by contrast, do ''not'' protect against STDs or PID.[13] Non Hormonal IUDs are considered safe to use while breastfeeding [1][Copper IUDs while nursing]
Contraindications
The WHO ''Medical Eligibility Criteria for Contraceptive Use'' and RCOG Faculty of Family Planning & Reproductive Health Care (FFPRHC) ''UK Medical Eligibility Criteria for Contraceptive Use'' list the following as conditions where insertion of a copper IUD is not usually recommended (category 3) or conditions where a copper IUD should not be inserted (category 4):[14][15]
Category 3. Conditions where the theoretical or proven risks usually outweigh the advantages of inserting a copper IUD:
★ Postpartum between 48 hours and 4 weeks (increased IUD expulsion rate with delayed postpartum insertion)
★ Benign gestational trophoblastic disease
★ Ovarian cancer
★ Very high individual likelihood of exposure to gonorrhea or chlamydial STIs
★ AIDS (unless clinically well on anti-retroviral therapy)
Category 4. Conditions which represent an unacceptable health risk if a copper IUD is inserted:
★ Pregnancy
★ Postpartum puerperal sepsis
★ Immediately post-septic abortion
★ Before evaluation of unexplained vaginal bleeding suspected of being a serious condition
★ Malignant gestational trophoblastic disease
★ Cervical cancer (awaiting treatment)
★ Endometrial cancer
★ Distortions of the uterine cavity by uterine fibroids or anatomical abnormalities
★ Current PID
★ Current purulent cervicitis, chlamydial infection, or gonorrheal STIs
★ Known pelvic tuberculosis
Adverse reactions have been reported in women with metal allergies, both copper[16] and nickel.[17] An anecdotal report on a LiveJournal community group journal states that the wires wrapped around the T-frame of the ParaGard IUD are nickel wires plated with copper.[18]
While nulliparous women (women who have never given birth) are somewhat more likely to have side effects, this is not a contraindication for IUD use.
Some doctors prefer to insert the IUD during menstruation to verify that the woman is not pregnant at the time of insertion. However, IUDs may safely be inserted at any time during the menstrual cycle as long as it is reasonably certain the woman is not pregnant.[19] Insertion may be more comfortable if done midcycle, when the cervix is naturally dilated.[20]
Side effects and complications
Insertion of the IUD may introduce bacteria into the uterus. The insertion process carries a small, transient increased risk of pelvic inflammatory disease in the first 20 days following insertion. It is very important that the provider use proper infection-prevention techniques during insertion.[21] Antibiotics should be given before insertion to women at high risk for endocarditis (inflammation of the membrane lining the heart), but should not be used routinely.[22]
During the placement appointment, the cervix is dilated in order to sound (measure) the uterus and insert the IUD. Cervix dilation is uncomfortable and, for some women, painful. Doctors often advise women to take painkillers before the procedure to reduce discomfort, and some will use a local anaesthetic.
After IUD insertion, menstrual periods are often heavier, more painful, or both - especially for the first few months after they are inserted. On average, menstrual blood loss increases by 20–50% after insertion of a copper-T IUD; increased menstrual discomfort is the most common medical reason for IUD removal.[23]
Complications include expulsion and uterine perforation. Uterine perforation is generally caused by an inexperienced provider and is very rare. Expulsion is more common in younger women, women who have not had children, and when an IUD is inserted immediately after childbirth or abortion. Women should check the string of the IUD at least once per menstrual cycle to verify that it is still in place.
The string(s) may be felt by some men during intercourse. If this is problematic, the provider may cut the strings even with the cervix, so they cannot be felt. Shortening the strings does prevent the woman from checking for expulsion, however.
The risk of ectopic pregnancy to a woman using an IUD is lower than the risk of ectopic pregnancy to a woman using no form of birth control. However, of pregnancies that do occur during IUD use, a higher than expected percentage (3–4%) are ectopic.[24]
Although the pregnancy rate during IUD use is very low (less than 1% per year), it is not a 100% effective method of birth control. If pregnancy does occur, presence of the IUD increases the risk of miscarriage, particularly during the second trimester. It also increases the risk of premature delivery. These increased risks end if the IUD is removed after pregnancy is discovered. Although the Dalkon Shield IUD was associated with septic abortions (infections associated with miscarriage), other brands of IUD are not. IUDs are also ''not'' associated with birth defects or other pregnancy complications.[25]
Use as emergency contraception
Intrauterine devices can be used as emergency contraception to prevent pregnancy up to 5 days after unprotected sexual intercourse, or sexual intercourse during which the primary contraception is believed to have failed (e.g. a condom was used, but it broke). Insertion of a copper-T IUD as emergency contraception is more than 99% effective, making it more effective than emergency contraceptive pills ('ECP' or 'morning-after pill').
Popularity
The IUD is the world's most widely used method of reversible birth control,
currently used by nearly 160 million women (just over two-thirds of whom are in China where it is the most widely used birth control method, surpassing sterilization). Usage in many countries has been measured by surveys of married women of reproductive age. In this population, IUD use ranges from 5% in Belgium, to 18% in Scandinavia, 30% in Russia and China, and 40% in Kazakhstan.[26]
In the U.S., the ParaGard T 380A was approved by the FDA in 1984 and became available for use in 1988. It is still the only copper IUD approved for use in the U.S., and was used by 1.3% of women of reproductive age in a 2002 U.S. survey.[27] A wider variety of IUDs is available outside of the U.S. In the U.K., for example, seven brands are available: Flexi-T 300, Multi-Safe 375, Multi-Load Cu 375, Neo-Safe T380, Nova T 380, T-Safe 380A, and GyneFix - also called FlexiGard 330 or CuFix PP330.[28]
Hormonal uterine devices
Main articles: IntraUterine System
Hormonal uterine devices do not increase bleeding as inert and copper-containing IUDs do. Rather, they reduce menstrual bleeding or prevent menstruation altogether, and can be used as a treatment for menorrhagia (heavy periods).
Although use of IntraUterine Systems results in much lower systemic progestogen levels than other very-low-dose progestogen-only hormonal contraceptives, they might possibly have some of the same side effects.
Progestasert was the first hormonal uterine device, developed in 1976[29] and manufactured until 2001.[30] It released progesterone, was replaced annually, and had a failure rate of 2% per year.[31]
As of 2007, the LNG-20 IUS - marketed as Mirena by Bayer - is the only IntraUterine System available. First introduced in 1990, it releases levonorgestrel (a progestogen) and may be used for five years.
A lower-dose T-shaped IntraUterine System named Femilis is being developed by Contrel, a Belgian company. Contrel also manufactures the FibroPlant-LNG, a frameless IUS. FibroPlant is anchored to the fundus of the uterus as the GyneFix IUD is. Although a number of trials have shown positive results, FibroPlant is not yet commercially available.[32]
History
Presenters at a family planning conference told a tale of Arab traders inserting small stones into the uteruses of their camels to prevent pregnancy. Although the story has been repeated as truth, it has no basis in history and was meant only for entertainment purposes.[33]
Precursors to IUDs were first marketed in 1902. Developed from stem pessaries (where the stem held the pessary in place over the cervix), the 'stem' on these devices actually extended into the uterus itself. Also known as interuterine devices (because they occupied both the vagina and the uterus), they had high rates of infection and were condemned by the medical community.[34]
The first intrauterine device (contained entirely in the uterus) was described in a German publication in 1909, although the author appears to have never marketed his product.[35]
In 1929, Dr. Ernst Gräfenberg of Germany published a report on an IUD made of silk suture. He had found a 3% pregnancy rate among 1,100 women using his ring. In 1930, Dr. Gräfenberg reported a lower pregnancy rate of 1.6% among 600 women using an improved ring wrapped in silver wire. Unbeknownst to Dr. Gräfenberg, the silver wire was contaminated with 26% copper. Copper's role in increasing IUD efficacy would not be recognized until nearly 40 years later.
In 1934, Japanese physician Tenrei Ota developed a variation of the ''Gräfenberg ring'' that contained a supportive structure in the center. The addition of this central disc lowered the IUD's expulsion rate. These devices still had high rates of infection, and their use and development was further stifled by World War II politics: contraception was forbidden in both Nazi Germany and Axis-allied Japan. The Western world did not learn of the work by Gräfenberg and Ota until well after the war ended.35
The first plastic IUD, the ''Marguiles Coil'' or ''Marguiles Spiral'', was introduced in 1958. This device was somewhat large, causing discomfort to a large proportion of women users, and had a hard plastic tail, causing discomfort to their male partners. The ''Lippes Loop'', a slightly smaller device with a monofilament tail, was introduced in 1962 and gained in popularity over the Marguiles device.34
The stainless steel single-ring IUD was developed in the 1970s[36] and widely used in China because of low manufacturing costs. The Chinese government banned production of steel IUDs in 1993 due to high failure rates (up to 10% per year).[37]7
Dr Howard Tatum, in the USA, conceived the plastic T-shaped IUD in 1968. Shortly thereafter Dr Jaime Zipper, in Chile, introduced the idea of adding copper to the devices to improve their contraceptive effectiveness.34[38] It was found that copper-containing devices could be made in smaller sizes without compromising effectivesness, resulting in fewer side effects such as pain and bleeding.[39] T-shaped devices had lower rates of expulsion due to their greater similarity to the shape of the uterus.35
The poorly designed Dalkon Shield plastic IUD (which had a multifilament tail) was manufactured by the A. H. Robins Company and sold by Robins in the United States for three and a half years from January 1971 through June 1974, before sales were suspended by Robins on June 28, 1974 at the request of the FDA because of safety concerns following reports of 110 septic spontaneous abortions in women with the Dalkon Shield in place, seven of whom had died.[40][41]
Robins stopped international sales of the Dalkon Shield in April 1975.[42]
Second-generation copper-T IUDs were also introduced in the 1970s. These devices had higher surface areas of copper, and for the first time consistently achieved effectiveness rates of greater than 99%. Worldwide today, with the exception of the new GyneFix, this is the only type of IUD available.9
See also
★ Vas-occlusive contraception
External links
★ Association of Reproductive Health Professionals' Clinical Proceedings: New Developments in Intrauterine Contraception
★ Population Reports: New Attention to the IUD—Johns Hopkins INFO Project, 2006
★ IUD Toolkit—USAID's Maximizing Access & Quality Project
★ Video of IUD being inserted - from University of Florida, Department of Obstetrics and Gynecology
Footnotes
1. What are the most widely used contraceptive methods across the world?
2. The intrauterine device (IUD)-worth singing about, World Health Organization, , , Progress in Reproductive Health Research, 2002
3. Long-term reversible contraception. Twelve years of experience with the TCu380A and TCu220C, World Health Organization, , , Contraception, 1997
4. IUDs—an update, Treiman K, Liskin L, Kols A, Rinehart W, , , Popul Rep B, 1995
5. Hormonally impregnated intrauterine systems (IUSs) versus other forms of reversible contraceptives as effective methods of preventing pregnancy, , R, French, Cochrane Database of Systematic Reviews,
6. Nova T380 Patient information leaflet (PIL) Schering
7. IUDs-An Update. Chapter 2.3: Effectiveness.
8. Frameless versus classical intrauterine device for contraception, , PA, O'Brien, Cochrane Database of Systematic Reviews,
9. IUDs—An Update. Chapter 1: Background.
10. Mechanisms of the Contraceptive Action of Hormonal Methods and Intrauterine Devices (IUDs)
11. IUDs Block Fertilization
12. Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects, Stanford J, Mikolajczyk R, , , Am J Obstet Gynecol, 2002 , which cites:
: Early pregnancy factor as a monitor for fertilization in women wearing intrauterine devices, Smart Y, Fraser I, Clancy R, Roberts T, Cripps A, , , Fertil Steril, 1982
13. Intrauterine devices and pelvic inflammatory disease: an international perspective, Farley TM, Rosenberg MJ, Rowe PJ, Chen JH, Meirik O, , , Lancet, 1992
Intrauterine device and upper-genital-tract infection, Grimes DA, , , Lancet, 2000
Yen and Jaffe's Reproductive Endocrinology, Mishell Jr., Daniel R., , , Elsevier Saunders, 2004, ISBN 0-7216-9546-9
Contraceptive Technology, Grimes, David A., , , Ardent Media, 2004, ISBN 0-9664902-5-8
A Clinical Guide for Contraception, Speroff, Leon; Darney, Philip D., , , Lippincott Williams & Wilkins, 2005, ISBN 0-7817-6488-2
Harrison's Principles of Internal Medicine, Hall, Janet E., , , McGraw-Hill, 2005, ISBN 0-07-139140-1
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Soper, David E.; Mead, Philip B., , , Elsevier Chuchill Livingston, 2005, ISBN 0-443-06643-4
Endocrinology, Glasier, Anna, , , Elsevier Saunders, 2006, ISBN 0-7216-0376-9
Berek & Novak's Gynecology, Stubblefield, Phillip G.; Carr-Ellis, Sacheen; Kapp, Nathalie, , , Lippincott Williams & Wilkins, 2007, ISBN 0-7817-6805-5
14. Medical Eligibility Criteria for Contraceptive Use, WHO, , , Reproductive Health and Research, WHO, 2004, ISBN 92-4-156266-8
15. The UK Medical Eligibility Criteria for Contraceptive Use (2005/2006) FFPRHC
16. A case of allergy to a copper-medicated IUD. Etiopathogenetic and clinical aspects, Pacilli L, Graffino W, Poggio A, Arrotta S, , , Minerva Ginecol, 1981
17. Cutaneous eruptions and intrauterine contraceptive copper device., Frentz G, Teilum D, , , Acta Derm Venereol, 1980
Comparative parameters of fertility regulation as related to STD / HIV infections. An overview., Merino G, Bailon R, Correu S, , , Adv Contracept Deliv Syst, 1991
18. ParaGard / Nickel connection??
19. IUDs-An Update. Chapter 3: Insertion.
20. Understanding IUDs
21. IUDs—An Update. Sidebar: Infection Prevention for IUD Insertion and Removal.
22. IUDs—An Update. Sidebar: Procedures for Providing IUDs.
23. IUDs-An Update. Chapter 2.5: Bleeding and Pain.
24. IUDs-An Update. Chapter 2.9:Ectopic Pregnancies.
25. IUDs-An Update. Chapter 2.8: Intrauterine Pregnancy.
26. IUDs—An Update. Worldwide Use - Developed Countries. Table 2: Worldwide Use of IUDs.
27. Fertility, Family Planning, and Reproductive Health of U.S. Women: Data From the 2002 National Survey of Family Growth, , A, Chandra, Vital Health Stat, 2005 See Table 56.
28. Contraceptive coils (IUDs)
29. IUDs—An Update. Chapter 2: Types of IUDs.
30. Contraceptive Concerns
31. Birth Control Options: The Progestasert Intrauterine Device (IUD)
32. New Contraceptive Choices, , , , Population Reports, INFO Project, Center for Communication Programs, April 2005 Chapter 9: Intrauterine Devices.
33. A History of Birth Control Methods , which cites:
Contraceptives, , Patricia, Thomas, Medical World News,
34. History of the IUD
35. Evolution and Revolution: The Past, Present, and Future of Contraception, , , , Contraception Online (Baylor College of Medicine), 2000
36. Ultrasound Interactive Case Study: Ring IUD (Has pictures of various IUD designs.)
37. The cost of IUD failure in China, , J., Kaufman, Studies In Family Planning, 1993 May-Jun
38. Importance of intrauterine contraception (Has pictures of many IUD designs, both historic and modern.)
39. IUDs—An Update. Chapter 1: Background.
40. Another look at the Dalkon Shield: meta-analysis underscores its problems, Sivin I, , , Contraception, 1993
41. A Crime Against Women. A. H. Robins and the Dalkon Shield, Mintz, Morton, , , Multinational Monitor, 1986
42. New Attention to the IUD: Expanding Women’s Contraceptive Options To Meet Their Needs, Salem R, , , Popul Rep B, 2006
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psst.. try this: add to faves
