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'Isabella' (1400 – February 28 1453) was Duchess of Lorraine from 1431 to her death.
She was a daughter of Charles II, Duke of Lorraine and Margaret of the Palatinate. Her maternal grandparents were Rupert of Germany and Elisabeth of Nuremberg, daughter of Burgrave Frederick V of Nuremberg and Elisabeth of Meissen.
Isabella inherited the duchy from her father and ruled with her husband, Duke René of Anjou, also Duke of Bar and King of Naples. During his absence, she acted as regent for his domains. She led an army to rescue her husband from Philip III, Duke of Burgundy.
They had the following issue:

★ John II of Anjou and King of Naples (1425-1470)

★ Yolande of Anjou (1428-1483), married Frederick of Lorraine, count of Vaudemont; mother of duke René II of Lorraine

★ Margaret of Anjou (1429-1482), married king Henry VI of England

★ plus seven others who died in childhood
'See also:' Dukes of Lorraine family tree

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References

★ Salmonson, Jessica Amanda.(1991) ''The Encyclopedia of Amazons''. Paragon House. Page 126-7. ISBN 1-55778-420-5