The following is the 'list of Major League Baseball leaders in career
.
| Rank | Pitcher | Wins | Teams played for | Seasons played |
|---|
| 1 | Cy Young | 511 | Cleveland (NL), St. Louis (NL), Boston (AL), Cleveland (AL), Boston (NL) | 1890-1911 |
| 2 | Walter Johnson | 417 | Washington (AL) | 1907-27 |
| 3 | Christy Mathewson | 373 | N.Y. Giants, Cincinnati (NL) | 1900-16 |
| Grover "Pete" Alexander | 373 | Philadelphia (NL), Chicago (NL), St. Louis (NL) | 1911-30 |
| 5 | Jim "Pud" Galvin | 364 | St. Louis (NL), Pittsburgh Burghers, Pittsburgh | 1875-92 |
| 6 | Warren Spahn | 363 | Boston/Milwaukee, New York (NL), San Francisco | 1942-65 |
| 7 | Kid Nichols | 361 | Boston (NL), St. Louis (NL), Philadelphia (NL) | 1890-1906 |
| 8 | Roger Clemens† | 354 | Boston (AL), Toronto, New York (AL), Houston (NL) | 1984- |
| 9 | Greg Maddux† | 345 | Atlanta, Chicago (NL), Los Angeles (NL), San Diego | 1986- |
| 10 | Tim Keefe | 342 | Troy, New York (AA), N.Y. Gothams/Giants, Philadelphia (NL) | 1880-93 |
| 11 | Steve Carlton | 329 | St. Louis (NL), Philadelphia (NL), Chicago (AL), San Francisco, Cleveland (AL), Minnesota | 1965-88 |
| 12 | John Clarkson | 328 | Worcester, Chicago (NL), Boston (NL), Cleveland (NL) | 1882-94 |
| 13 | Eddie Plank | 326 | Philadelphia (AL), St. Louis (FL), St. Louis (AL) | 1901-17 |
| 14 | Don Sutton | 324 | Los Angeles, Houston, Milwaukee (AL), California, Oakland | 1966-88 |
| Nolan Ryan | 324 | New York (NL), California, Houston, Texas | 1966, 1968-93 |
| 16 | Phil Niekro | 318 | Milwaukee/Atlanta, New York (AL), Cleveland (AL), Toronto | 1964-87 |
| 17 | Gaylord Perry | 314 | San Francisco, Cleveland (AL), Texas, San Diego, New York (AL), Atlanta, Seattle, Kansas City | 1962-83 |
| 18 | Tom Seaver | 311 | New York (NL), Cincinnati (NL), Chicago (AL), Boston (AL) | 1967-86 |
| 19 | Charley Radbourn | 309 | Providence, Boston (NL), Boston (AA), Cincinnati (NL) | 1881-91 |
| 20 | Mickey Welch | 307 | Troy, N.Y. Gothams/Giants | 1880-92 |
| 21 | Tom Glavine† | 303 | Atlanta, New York (NL) | 1987- |
| 22 | Lefty Grove | 300 | Philadelphia (AL), Boston (AL) | 1925-41 |
| Early Wynn | 300 | Washington (AL), Cleveland (AL), Chicago (AL) | 1939, 1941-63 |
| 24 | Bobby Mathews | 297 | Fort Wayne, Baltimore (AA), N.Y. Mutuals, Providence, Boston (NL), Philadelphia (AA) | 1871-87 |
| 25 | Tommy John | 288 | Cleveland (AL), Chicago (AL), Los Angeles, New York (AL), California, Oakland | 1963-89 |
| 26 | Bert Blyleven | 287 | Minnesota, Texas, Pittsburgh, Cleveland (AL), California | 1970-92 |
| 27 | Robin Roberts | 286 | Philadelphia (NL), Baltimore (AL), Houston, Chicago (NL) | 1948-66 |
| 28 | Tony Mullane | 284 | Detroit (NL), Louisville, St. Louis (NL), Toledo, Cincinnati (NL), Baltimore (NL), Cleveland (NL) | 1881-94 |
| Fergie Jenkins | 284 | Philadelphia (NL), Chicago (NL), Texas, Boston (AL) | 1965-83 |
| Randy Johnson† | 284 | Montreal, Seattle, Houston, Arizona, New York (AL) | 1988- |
| 31 | Jim Kaat | 283 | Washington/Minnesota, Chicago (AL), Philadelphia (NL), New York (AL), St. Louis (NL) | 1959-83 |
| 32 | Red Ruffing | 273 | Boston (AL), New York (AL), Chicago (AL) | 1924-47 |
| 33 | Burleigh Grimes | 270 | Pittsburgh, Brooklyn (NL), N.Y. Giants, Boston (NL), St. Louis (NL), Chicago (NL), New York (AL) | 1916-34 |
| 34 | Jim Palmer | 268 | Baltimore (AL) | 1965-84 |
| 35 | Eppa Rixey | 266 | Philadelphia (NL), Cincinnati (NL) | 1912-33 |
| Bob Feller | 266 | Cleveland (AL) | 1936-56 |
| 37 | Jim McCormick | 265 | Indianapolis, Cleveland (NL), Cincinnati (UA), Chicago (NL), Providence, Pittsburgh | 1878-87 |
| 38 | Gus Weyhing | 264 | Philadelphia (AA), Brooklyn (PL), Philadelphia (NL), Louisville, Pittsburgh, Washington (AL), Brooklyn (NL), St. Louis (NL), Cincinnati (NL), Cleveland (AL) | 1887-1901 |
| 39 | Ted Lyons | 260 | Chicago (AL) | 1923-42, 1946 |
| 40 | Red Faber | 254 | Chicago (AL) | 1914-33 |
| Jack Morris | 254 | Detroit (AL), Minnesota, Toronto, Cleveland (AL) | 1977-94 |
| 42 | Carl Hubbell | 253 | N.Y. Giants | 1928-43 |
| 43 | Al Spalding | 252 | Boston (NL), Chicago (NL) | 1871-78 |
| 44 | Bob Gibson | 251 | St. Louis (NL) | 1959-75 |
| 45 | Vic Willis | 249 | Boston (NL), Pittsburgh, St. Louis (NL) | 1898-1910 |
| 46 | Jack Quinn | 247 | New York (AL), Boston (NL), Baltimore (Fed. Lg.), Chicago (AL), Boston (AL), Philadelphia (AL), Brooklyn (NL), Cincinnati | 1909-15, 1918-33 |
| Mike Mussina† | 247 | Baltimore (AL), New York (AL) | 1991- |
| 48 | Amos Rusie | 246 | Indianapolis (NL), N.Y. Giants, Cincinnati (NL) | 1889-1895, 1897-98, 1901 |
| Joe McGinnity | 246 | Baltimore (NL), Brooklyn (NL), New York (AL) | 1899-1908 |
| 50 | Jack Powell | 245 | Cleveland (NL), St. Louis (NL), St. Louis (AL), New York (AL) | 1897-1912 |
| Dennis Martinez | 245 | Baltimore (AL), Montreal, Cleveland (AL), Seattle, Atlanta | 1976-98 |
| 52 | Juan Marichal | 243 | San Francisco, Boston (AL), Los Angeles | 1960-75 |
| 53 | Herb Pennock | 240 | Philadelphia (AL), Boston (AL), New York (AL) | 1912-34 |
| Frank Tanana | 240 | California, Boston (AL), Texas, Detroit (AL), New York (AL), New York (NL) | 1973-93 |
| 55 | Mordecai Brown | 239 | St. Louis (NL), Chicago (NL), Cincinnati (NL), Brooklyn (PL), St. Louis (FL), Chicago (FL) | 1903-16 |
| 56 | Clark Griffith | 237 | Boston (AA), St. Louis (NL), Chicago (NL), Chicago (AL), New York (AL), Cincinnati (NL), Washington (AL) | 1891, 1893-1907, 1909, 1912-14 |
| Waite Hoyt | 237 | N.Y. Giants, Boston (AL), New York (AL), Detroit (AL), Philadelphia (AL), Brooklyn (NL), Pittsburgh | 1918-38 |
| David Wells† | 237 | Toronto, Detroit (AL), Cincinnati (NL), Baltimore (AL), New York (AL), Chicago (AL), San Diego, Boston (AL) | 1987- |
| 59 | Whitey Ford | 236 | New York (AL) | 1950, 1953-67 |
| 60 | Tommy Bond | 234 | Brooklyn (NA), Hartford, Boston (NL), Worcester, Boston (AA), Indianapolis (NL) | 1874-82, 1884 |
| 61 | Charlie Buffinton | 233 | Boston (NL), Philadelphia (NL), Boston (AA), Baltimore (NL) | 1882-92 |
| 62 | Will White | 229 | Boston (NL), Cincinnati (NL), Detroit (NL) | 1877-86 |
| "Sad" Sam Jones | 229 | Cleveland (AL), Boston (AL), New York (AL), St. Louis (AL), Washington (AL), Chicago (AL) | 1914-35 |
| Luis Tiant | 229 | Cleveland (AL), Minnesota, Boston (AL), New York (AL), California | 1964-82 |
| 65 | George Mullin | 228 | Detroit (AL), Washington (AL), Indianapolis (FL)/Newark | 1902-15 |
| Jamie Moyer† | 228 | Chicago (NL), Texas, St. Louis (NL), Baltimore (AL), Boston (AL), Seattle, Philadelphia (NL) | 1986- |
| 67 | Jim Bunning | 224 | Detroit (AL), Philadelphia (NL), Pittsburgh, Los Angeles | 1955-71 |
| Catfish Hunter | 224 | Kansas City/Oakland, New York (AL) | 1965-79 |
| 69 | Paul Derringer | 223 | St. Louis (NL), Cincinnati (NL), Chicago (NL) | 1931-45 |
| Mel Harder | 223 | Cleveland (AL) | 1928-47 |
| 71 | Hooks Dauss | 222 | Detroit (AL) | 1912-26 |
| Jerry Koosman | 222 | New York (NL), Minnesota, Chicago (AL), Philadelphia | 1967-85 |
| 73 | Joe Niekro | 221 | Chicago (NL), San Diego, Detroit (AL), Atlanta, Houston, New York (AL), Minnesota | 1967-88 |
| 74 | Jerry Reuss | 220 | St. Louis (NL), Houston, Pittsburgh, Los Angeles, California, Cincinnati, Chicago (AL), Milwaukee | 1969-90 |
| 75 | Bob Caruthers | 218 | St. Louis (AA), Brooklyn (NL), St. Louis (NL) | 1884-92 |
| Earl Whitehill | 218 | Detroit (AL), Washington (AL), Cleveland (AL), Chicago (NL) | 1923-39 |
| 77 | Freddie Fitzsimmons | 217 | N.Y. Giants, Brooklyn (NL) | 1925-43 |
| Mickey Lolich | 217 | Detroit (AL), New York (NL), San Diego | 1963-1976, 1978-79 |
| 79 | Wilbur Cooper | 216 | Pittsburgh, Chicago (NL), Detroit (AL) | 1912-26 |
| Charlie Hough | 216 | Los Angeles, Texas, Chicago (AL), Florida | 1970-94 |
| 81 | Stan Coveleski | 215 | Philadelphia (AL), Cleveland (AL), Washington (AL), New York (AL) | 1912, 1916-28 |
| Jim Perry | 215 | Cleveland (AL), Minnesota, Detroit (AL), Oakland | 1959-75 |
| Curt Schilling† | 215 | Baltimore (AL), Houston, Philadelphia (NL), Arizona, Boston (AL) | 1988- |
| 84 | Rick Reuschel | 214 | Chicago (NL), New York (AL), Pittsburgh, San Francisco | 1972-81, 1983-91 |
| 85 | Chief Bender | 212 | Philadelphia (AL), Baltimore (FL), Philadelphia (NL), Chicago (AL) | 1903-17, 1925 |
| 86 | Bobo Newsom | 211 | Brooklyn (NL), Chicago (NL), St. Louis (AL), Washington (AL), Boston (AL), Detroit (AL), Philadelphia (AL), New York (AL), N.Y. Giants | 1929-30, 1932, 1934-38, 1952-53 |
| Billy Pierce | 211 | Detroit (AL), Chicago (AL), San Francisco | 1945, 1948-64 |
| Bob Welch | 211 | Los Angeles, Oakland | 1978-94 |
| Kevin Brown | 211 | Texas, Baltimore (AL), Florida, San Diego, Los Angeles, New York (AL) | 1986, 1988-2006 |
| 90 | Jesse Haines | 210 | Cincinnati (NL), St. Louis (NL) | 1918, 1920-37 |
| Kenny Rogers† | 210 | Texas, New York (AL), Oakland, New York (NL), Minnesota, Detroit | 1989- |
| 92 | Don Drysdale | 209 | Brooklyn/Los Angeles | 1956-69 |
| Milt Pappas | 209 | Baltimore (AL), Cincinnati (NL), Atlanta, Chicago (NL) | 1957-73 |
| Vida Blue | 209 | Oakland, San Francisco, Kansas City (AL) | 1969-86 |
| 95 | Eddie Cicotte | 208 | Detroit (AL), Boston (AL), Chicago (AL) | 1905, 1908-20 |
| 96 | Carl Mays | 207 | Boston (AL), New York (AL), Cincinnati, N.Y. Giants | 1915-29 |
| Hal Newhouser | 207 | Detroit (AL), Cleveland (AL) | 1939-55 |
| Bob Lemon | 207 | Cleveland (AL) | 1946-58 |
| Pedro Martínez† | 207 | Los Angeles, Montreal, Boston (AL), New York (NL) | 1992- |
| 100 | John Smoltz † | 206 | Atlanta | 1988- |