LIVER FAILURE

'Liver failure' is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology. Two forms are recognised:^[1]

★ 'Acute liver failure' - development of hepatic encephalopathy (confusion, stupor and coma) and decreased production of proteins (such as albumin and blood clotting proteins) within four weeks of the first symptoms (such as jaundice) of a liver problem. "Hyperacute" liver failure is said to be present if this interval is 7 days or less, while "subacute" liver failure is said to be present if the interval is 5-12 weeks.

★ 'Chronic liver failure' usually occurs in the context of 'cirrhosis', itself potentially the result of many possible causes, such as excessive alcohol intake, hepatitis B or C, autoimmune, hereditary and metabolic causes.

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Reference

Reference

1. O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''Lancet'' 1993;342:273-5. PMID 8101303.