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'Maddalena de' Medici' (July 25 1473 - December 1528) was the daughter of Lorenzo de' Medici and Clarice Orsini.
Born in Florence, she was educated with his siblings to the humanistic cultures by figures such as Agnolo Poliziano. On February 25 1487 she married Franceschetto Cybo, son of Pope Innocent VIII. Thenceforth Maddalena lived in Rome but, after her father's death (1492), she resided also in Tuscany and Liguria.
Maddalena lived again mostly in Rome after the election of his brother Giovanni as Pope Leo X, and died dere in 1528. She was buried in St. Peter's Basilica by order of his nephew, Pope Clement VII.

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Franceschetto and Maddalena had seven children:
#Lucrezia Cybo (1489-1492)
#Clarice Cybo (1490-1492) born deformed, died as a child
#Innocenzo Cybo (1491-1550), Cardinal
#Lorenzo Cybo (1500-1549) Duke of Ferentillo, married Ricciarda I Malaspina and founded the Cybo Malaspina family
#Caterina Cybo (1501-1557), married the Duke of Camerino
#Ippolita Cybo (1503-1503)
#Giovanni Battista Cybo (1505-1550)