5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE

(Redirected from Methionine synthase)

'5-Methyltetrahydrofolate-homocysteine methyltransferase' or ('MTR') is an enzyme responsible for the production of methionine from homocysteine. MTR forms part of the S-adenosyl methionine cycle and is also called methionine synthase.

Contents

Function

See also

External links

Function

'MTR' contains the cofactor - methylcobalamin (MeB₁₂) and uses the substrates N5-methyl-tetrahydrofolate (N⁵-methyl-THF) and homocysteine.
The enzyme works in two steps in a ping-pong reaction. First, methylcobalamin is formed by a methyl group transfer from N⁵-mTHF with formation of MeB₁₂ and tetrahydrofolate (THF). In the second step, MeB₁₂ transfers this methyl group to (homocysteine), regenerating the cofactor cobalamin and releasing the product methionine

See also

★ methyltransferase

★ Arakawa's syndrome II

★ 5-methyltetrahydrofolate

External links

★ ENZYME: EC 2.1.1.13

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