MYCOLACTONE

'Mycolactone' is a polyketide-derived macrolide produced and secreted by the pathogenic mycobacteria ''M. ulcerans'', ''M. liflandii'', ''M. pseudoshottsii'', and a few ''M. marinum'' isolates.
The ''M. ulcerans'' toxins comprise a family of polyketide-derived macrolides, mycolactones, which are formed through condensation of two polyketide chains. Each isolate of ''M. ulcerans'' produces a characteristic mixture of mycolactone congeners. ''M. ulcerans strains'' from different geographic areas produce distinct patterns of mycolactone congeners. The structural heterogeneity in mycolactones is due to variations in the fatty acid side chain. The structure of the core lactone is invariant. A newly discovered mycobacterial pathogen isolated from laboratory colonies of ''Xenopus'' species with lethal infections produces a novel form of mycolactone, the ''Mycobacterium ulcerans'' macrolide toxin., Mve-Obiang A; Lee RE; Umstot ES; Trott KA; Grammer TC; Parker JM; Ranger BS; Grainger R; Mahrous EA; Small PLC, , , Infect. Immun., 2005
Genes for mycolactone biosynthesis form a contiguous 110-kb cluster (Fig. 1A) on a large plasmid. The lactone core is encoded by two polyketide synthase (Pks) genes, mlsA1 and mlsA2, and a third polyketide synthase gene, mlsB, encodes the fatty acid side chain. Three accessory genes are found in the mycolactone cluster. One of these, MUP053, encodes a p450 monooxygenase that is thought to produce the hydroxyl at C′-12 on the fatty acid side chain. The gene encoding a FabH-like, type III ketosynthase (KS), located upstream of mlsA1, encodes a putative “joinase” (MUP045), and a small type II thioesterase (TE II) gene (MUP037) is located between mlsA2 and mlsB.
Five categories have been described so far:

★ Mycolactone A/B (''M. ulcerans'' from Africa, Malaysia, ...)

★ Mycolactone C (8 Australian ''M. ulcerans'' isolates)

★ Mycolactone D (''M. ulcerans'' from Asia)

★ Mycolactone E (''M. liflandii'')

★ Mycolactone F (''M. pseudoshottsii'' and ''M. marinum'' from Israël)^[1]

Contents

References

References

1.
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F., Ranger BS; Mahrous EA; Mosi L; Adusumilli S; Lee RE; Colorni A; Rhodes M; Small PLC, , , Infect. Immun., 2006