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'Piero de' Medici' may refer to one of the following people.
There were two Medici known as 'Piero de' Medici':

★ Piero di Cosimo de' Medici (1416-1469) (the Gouty, ''also'' Piero I de' Medici), father of Lorenzo the Magnificent

★ Piero di Lorenzo de' Medici (1471-1503) (the Unfortunate, ''also'' Piero II de' Medici), son of Lorenzo the Magnificent