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EspañolPYROGLUTAMIC ACID
(Redirected from Pyroglutamate)
'Pyroglutamic acid' is an uncommon amino acid found in many proteins including bacteriorhodopsin. N-terminal glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for n-terminal sequencing using Edman chemistry (which requires a free primary amino group). The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
'Pyroglutamic acid' is an uncommon amino acid found in many proteins including bacteriorhodopsin. N-terminal glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for n-terminal sequencing using Edman chemistry (which requires a free primary amino group). The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
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