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EspañolRHO(D) IMMUNE GLOBULIN
(Redirected from Rhogam)
'Rho(D) Immune Globulin' is a medicine given by intermuscular injection which is used to prevent the immunological condition known as Rhesus disease (or hemolytic disease of newborn). It can prevent maternal sensitization by Rh D antigens on the surface of blood cells from a Rhesus positive fetus in a Rhesus negative mother. The medicine is an solution of IgG anti-D (anti-RhD) antibodies which binds and destroys fetal Rh D positive red blood cells that have passed through the placenta from the fetus to the maternal circulation. This prevents maternal B-cell activation and memory cell formation. With the widespread use Rho(D) Immune Globulin Rh disease of the fetus and newborn has almost disappeared.
RhoGAM was introduced by Ortho-Clinical Diagnostics, a subsidiary holding of Johnson and Johnson, and first administered on May 29, 1968. It has been estimated that with its use a perinatal mortality of about 10,000 cases per year in the US alone has been largely eliminated.
Rho(D) Immune Globulin is a derivative of human plasma. In the manufacturing process steps are taken to eliminate bacterial and viral contamination. In some patients it may trigger an allergic reaction. However, the possibility of transmission of Creutzfeldt-Jakob disease remains as a residual risk . The technique of Plasma Fractionation was founded by James F. Crispen, M.D.
The medication has a Food and Drug Administration (FDA) Pregnancy Category C. It is given by intramuscular injection as part of modern antenatal care and within 72 hours after childbirth.
RhoGAM and MICRhoGam are brand names of Johnson and Johnson. Other brand names are: BayRHo-D, Gamulin Rh, HypRho-D Mini-Dose, Mini-Gamulin Rh, Rhophylac, and WinRho SDF.
★ Rhesus blood group system
★ Blood types
★ Immunology
★ Rh disease
★ Thimerosal controversy
★ Profile on Dr. Crispen
★ Product Website
★ Product information
★ Green top guidelines for Rh disease prevention 2002 from the RCOG (UK)
★
'Rho(D) Immune Globulin' is a medicine given by intermuscular injection which is used to prevent the immunological condition known as Rhesus disease (or hemolytic disease of newborn). It can prevent maternal sensitization by Rh D antigens on the surface of blood cells from a Rhesus positive fetus in a Rhesus negative mother. The medicine is an solution of IgG anti-D (anti-RhD) antibodies which binds and destroys fetal Rh D positive red blood cells that have passed through the placenta from the fetus to the maternal circulation. This prevents maternal B-cell activation and memory cell formation. With the widespread use Rho(D) Immune Globulin Rh disease of the fetus and newborn has almost disappeared.
| Contents |
| History |
| Human blood product |
| Use |
| Brand names |
| See also |
| External links |
History
RhoGAM was introduced by Ortho-Clinical Diagnostics, a subsidiary holding of Johnson and Johnson, and first administered on May 29, 1968. It has been estimated that with its use a perinatal mortality of about 10,000 cases per year in the US alone has been largely eliminated.
Human blood product
Rho(D) Immune Globulin is a derivative of human plasma. In the manufacturing process steps are taken to eliminate bacterial and viral contamination. In some patients it may trigger an allergic reaction. However, the possibility of transmission of Creutzfeldt-Jakob disease remains as a residual risk . The technique of Plasma Fractionation was founded by James F. Crispen, M.D.
Use
The medication has a Food and Drug Administration (FDA) Pregnancy Category C. It is given by intramuscular injection as part of modern antenatal care and within 72 hours after childbirth.
Brand names
RhoGAM and MICRhoGam are brand names of Johnson and Johnson. Other brand names are: BayRHo-D, Gamulin Rh, HypRho-D Mini-Dose, Mini-Gamulin Rh, Rhophylac, and WinRho SDF.
See also
★ Rhesus blood group system
★ Blood types
★ Immunology
★ Rh disease
★ Thimerosal controversy
External links
★ Profile on Dr. Crispen
★ Product Website
★ Product information
★ Green top guidelines for Rh disease prevention 2002 from the RCOG (UK)
★
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