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'Santa Isabel' is the Spanish and Portuguese name of one of two Roman Catholic saints, Saint Isabel of France and Saint Isabel of Aragon. Various places have been named for either of such persons. These include:

★ Santa Isabel, Buenos Aires, a settlement in General Alvear Partido in Argentina

★ Santa Isabel, Espírito Santo, a town in Espírito Santo state, Brazil

★ Santa Isabel, Goiás, a town in Goiás state, Brazil

★ Santa Isabel Island, an island in the Solomon Islands

★ Santa Isabel, Puerto Rico, a southern municipality in Puerto Rico

★ Santa Isabel, São Paulo, a town in São Paulo state, Brazil

★ Santa Isabel, Trujillo, Trujillo State, Venezuela

★ Santa Isabel (volcano), a volcano in Colombia

★ Former name of Malabo, the capital of Equatorial Guinea

★ Former name of Pico Basilé, highest mountain of Equatorial Guinea