SORBITOL

'Sorbitol', also known as 'glucitol', is a sugar alcohol the body metabolises slowly. It is obtained by reduction of glucose changing the aldehyde group to an additional hydroxyl group hence the name ''sugar alcohol''.

Contents

Use as a sweetener

Use as a laxative

Clinical significance

Other uses

See also

External links

References

Use as a sweetener

Sorbitol is used in various cough syrups, and is usually listed under the inactive ingredients. Too much sorbitol (from 10 to 50g, or more for adults) can cause gastro-intestinal problems.
Sorbitol is a sugar substitute often used in diet foods (including diet drinks and ice cream) and sugar-free chewing gum. It also occurs naturally in many stone fruits and berries from trees of the genus Sorbus^[1]. Sorbitol is also referred to as a nutritive sweetener because it provides calories or energy to the diet: 2.6 calories (11 kilojoules) per gram versus the average 4 calories (17 kJ) of sugar and starch, while retaining 60% of the sweetness. As a food additive it has an E number E420, categorized as a sweetener, emulsifier and humectant, grouped under "Other natural agents".

Use as a laxative

Sorbitol can be used as a non-stimulant laxative by either in oral suspension or suppository form. The drug works by drawing water into the large intestine, thereby stimulating bowel movements.^[2] Sorbitol has been determined safe to use in the elderly. ^[3]

Clinical significance

Ingesting large amounts of sorbitol can lead to some abdominal pain, gas, and mild to severe diarrhea. Sorbitol can also aggravate irritable bowel syndrome and fructose malabsorption.
Even in the absence of dietary sorbitol, cells also produce sorbitol naturally. When too much sorbitol is produced inside cells, it can cause damage.^[4] Diabetic retinopathy and neuropathy may be related to excess sorbitol in the cells of the eyes and nerves. The source of this sorbitol in diabetics is excess glucose, which goes through the polyol pathway.

Other uses

Sorbitol is often used in modern cosmetics as a humectant and thickener. Some transparent gels can only be made with sorbitol as it has a refractive index sufficiently high for transparent formulations. It is also used as a humectant in some cigarettes.
Sorbitol is used as a cryoprotectant additive (mixed with sucrose and sodium polyphosphates) in the manufacture of surimi, a highly refined, uncooked fish paste most commonly produced from Alaska (or walleye) pollock (''Theragra chalcogramma'').
Furthermore, Sorbitol, combined with Kayexalate, helps the body rid itself of excess potassium ions in a hyperkalemic state. The Kayexalate exchanges sodium ions for potassium ions in the bowel, while sorbitol helps to eliminate it.
Sorbitol when combined with potassium nitrate has found some success as an amateur solid rocket fuel.^[5]
Sorbitol is identified as a potential key chemical intermediate ^[6] from biomass resources. Complete reduction of sorbitol opens the way to alkanes such as hexane which can be used as a biofuel. Sorbitol itself provides much of the hydrogen required for the transformation.
:19 C₆O₆H₁₄ → 13 C₆H₁₄ + 36 CO₂ + 42 H₂O
The above chemical reaction is exothermic and 1.5 mole of sorbitol generates 1 mole of hexane. When hydrogen is co-fed, no carbon dioxide production takes place.

See also

★ Mannitol

★ Xylitol

External links

★ NIH Diabetes dictionary — see entry on sorbitol

References

1. Lehninger ''Principles of Biochemistry'', Nelson and Cox, Fourth Edition
2. http://www.cancer.org/docroot/CDG/content/CDG_sorbitol.asp
3. Lederle FA: Epidemiology of constipation in elderly patients. Drug utilization and cost-containment strategies. Drugs and Ageing 6:465-469, 1995.
4. Sorbitol: a hazard for diabetics? Nutrition Health Review
5. Richard Nakka's Experimental Rocketry Web Site
6. ''Production of Liquid Hydrocarbons from Biomass '' Jürgen O. Metzger Angewandte Chemie International Edition Volume 45, Issue 5 , Pages 696 - 698 '2005' Abstract