SPIRAPRIL

'Spirapril hydrochloride' (Renormax®) is an ACE inhibitor antihypertensive drug used to treat hypertension.
Like many ACE inhibitors, this is a prodrug which is converted to the active metabolite spiraprilat following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes which may allow for greater use in patients with renal impairment.^[1]
However data on its effect upon the renal function is conflicting.^[2]

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Footnotes

1. Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension., Shohat J, Wittenberg C, Erman A, Rosenfeld J, Boner G, , , Scand J Urol Nephrol, 1999
2. Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension., Noble S, Sorkin E, , , Drugs, 1995