V-ERBA-RELATED GENE

The protein encoded by the 'v-erbA-related gene' ('ear-2') is a member of the nuclear receptor family of intracellular transcription factors.^[1]
Comparatively little is known about ear-2, but is has been shown to function as a coregulator of other nuclear receptors.^[2][3]

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References

1. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other, Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T, , , Nucleic Acids Res., 1988
2. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function, Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY, , , Mol. Cell. Biol., 2000
3. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription, Liu X, Huang X, Sigmund CD, , , Circ. Res., 2003

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