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'William I of Hesse' (German: ''Wilhelm'') (4 July 1466 - 8 February 1515) was the Landgrave of Hesse from 1471 to 1493.
His parents were Louis the Frank (1438-1471) and Mechthild, daughter of Count Louis I of Württemberg. In 1488 he married Anna von Braunschweig with whom he had five daughters. After contracting syphilis, he abdicated in favor of his brother William II on 3 June 1493.