Short answer ... definitely NOT !!!
Tried both, cruised on many occasions. Best cruises are on small ships with
a good crew to passenger ratio.
There are many reasons for this opinion.

Large ships have all the amenities that the smaller ones have and then some.
On a big ship, if you enjoy lining up with the crowd, you might get to enjoy some of them.
Smaller ships with fewer passengers allow for better passenger use of the facilities such as the gym,
the spa area, the buffet area, etc. without having to compete for space with other passengers.

Smaller ships go to places that the biggie's can't go. The smaller ports are most often the most interesting and will give you the most personal and unique visiting experience.

I could go on, but leave it said that the smaller ships are more personal, you meet more people you can get to know well, and the service is better.

It depends on what you want from your cruise. A mega-ship could be the destination itself - many people seem to have little interest in which ports they sail to, they just want to experience all the facilities that the ship offers. One of the normal-sized large ships (2,000-2,500 passengers) will allow you to experience the ports better as you're not jostling through massive crowds of people. And for a real up-close-and-personal experience of the region you're sailing in, a small ship is the way to go (at a far higher cost).

I agree with Murray. It depends on what you like personally. If you are with a family or multi generational, then the larger ships, especially the really big ones like Royal Caribbean's Oasis Class ships, have so many options that everyone can find something to occupy them. They have also taken into account the larger passenger size and have so many options to reserve in advance, you never feel crowded. Take this from one who has been on it when it was full!

The smaller ships are more for those that have been around the ships and are looking for something new. As MikeSr said earlier, they can get into ports the larger ships can't go so you get more variation in itinerary. The larger ships have become the destination, while the smaller ships are about the port calls. If you are doing the Caribbean, I always tell my clients the shore excursions are only a few hours long so the amenities on the ships matter. You want a ship that has a lot to do when you are not in port. If you are going to Europe or Asia, where you are off the ship all day long exploring, then a smaller ship will do, since you are mainly sleeping and eating breakfast and dinner there and the dinner might even be a maybe.

Hope this helps. If you have more questions, just ask.

Well I say a mega cruise because there is a lot more to see and do.Just like there is a soul train cruise this time next year.So if you book now you will have a thrill of a life time.Small ships are to me more personal for couples or small tours ,or just want to have some alone time to your self.This mega cruise will have some ofthe hottest sining groups.Example- The four tops plus many many more.Go to Facebook and be my friend Shorty Moore and you will see ad for the Soul train cruise.or look it up.The Soul train cruise 2013.

This is like asking someone which is better - apples or oranges. Both have advantages and disadvantages. I have been on both the mega cruise ships (Oasis of the Seas) and a smaller boutique, luxury ship (Azamara Journey). While I prefer the smaller ships, I enjoyed the Oasis immensely. As a travel adviser I have to qualify my clients as to what they are looking for and then help them make a selection. The most important advice I can give is whatever cruise ship you choose expect to have a good time and you will.

We all know that smaller is better! I remember many occasions when I was onboard a small ship (Windjammer or small yacht)when we encountered the large 'cities on the oceans' and seeing a few thousand line up to disembark to buy t-shirts whilst we simply sailed to a nice quiet beach for some nice quiet snorkeling and bbq.
I could never see myself on any of these behemoths enclosed in an airconditioned hotel when I could be on the deck of 3 or 4 masted sailing ship... Royal Clipper et al..unless on a transatlantic 'voyage' when you only get on once and get off once...in 5 or 6 days...

Tony, re your comment "We all know that smaller is better!" No, we don't all know that - it's right for some people, though.

This question is double-sided and depends on what type of experience your client is seeking. Using large ship as a hotel and destination or sailing on small ship for intermingling with fellow passengers. Both are great, but very different

Both have much to offer depending on how you like to travel. Mega ships offer many activities that small ships may not. Big ships may not offer ports-of-call that small ships do. Average age of passengers on mega ships will be lower than on smaller ships. The smaller the ship the older the crowd, same as the longer the cruise the older the crowd. I am talking from experience as I've been on 16 cruises.
I hope this helps.

Milan Bartosz
Expedia Cruise Ship Centers
www.milanbartosz.cruiseshipcenters.com

The answer to this question is really personal preference - as well as location. Some of the larger ships can not go to very specialized locations - but other than that it depends on your lifestyle and how active you would like to be during your vacation. The larger the ship the more variety they offer for you and your family.